Side Effects

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Top 10 Side Effects of Mood Stabilizers

The following is a list of the most frequently encountered side effects experienced by patients taking mood stabilizers and the medications that often cause them.

Side effect Medication How to control side effects
1. Drowsiness Carbamazepine
Oxcarbazepine
Valproate
Lamotragine
Topiramate
Take dose at bedtime
If condition is stable talk to doctor about whether a lower dose would be ok
2.Upset stomach Diarrhea
Lithium
Valproic Acid
Carbamazepine
Oxcarbazepine
Lamotrigine Take with food. Start the medication slowly
Take coated tablet if one is available
Take in divided doses rather than one dose
Ask the physician is a lower dose is possible
3. Tremor Lithium
Valproic acid
Take in divided doses
See if lower dose is required
4. Headache Oxcarbazepine Valproate
Lamotrigine
Topiramate
Divide the dose
Take with food
Take a pain medication
5. Rash Carbamazepine Oxcarbazepine
Valporic acid
Lithium
Lamotrigine Rash may be mild to severe.
Stop medication and contact physician immediately.
6. Dizziness All mood stabilizers Have the blood level of the medication checked
Take in divided doses rather than once daily
Stand up slowly
7. Confusion Topiramate
Lithium
Valproic Acid
Doctor may choose another medication
Doctor may want to check dose level
8. Weight gain Olanzapine
Quetiapine
Risperidone
Valproic acid
Lithium Doctor may choose another medication
Make healthy food choices
Try to exercise 5 or more times weekly
9. Muscle stiffness, restlessness, tremor while at rest Clozapine
Risperidone
Olanzapine
Aripiprazole
Doctor may choose another medication or lower the dose.
Benztropine or diphenhydramine may be added to control symptoms
10. High blood sugar high cholesterol levels Clozapine
Risperidone
Olanzapine
Quetiapine
Have blood sugar and cholesterol levels monitored every three months
Make healthy food choices